Christina Applegate

Nominated for the 2009 Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series

Joined Rainn Wilson in the comedy "The Rocker"

Played a 30-year-old psychiatrist who suffered from amnesia in the ABC comedy, "Samantha Who?"; also produced; earned Golden Globe (2008, 2009), SAG (2008, 2009) and Emmy (2008, 2009) nominations for Best Actress in a Comedy Series

Co-starred with husband Johnathon Schaech in the CBS movie "James Patterson's Suzanne's Diary for Nicholas"

Made her Broadway debut as Charity Hope Valentine in "Sweet Charity"; received a Tony nomination for her role

Received an Emmy nomination for Outstanding Guest Actress in a Comedy series for her role on "Friends"

Starred opposite Will Ferrell as an ambitious female journalist in the comedy "Anchorman"

Appeared alongside Gwyneth Paltrow as flight attendants in the comedy "A View from the Top"

Co-starred with Cameron Diaz and Selma Blair in the comedy "The Sweetest Thing"

Had a recurring role as Rachel's sister in the NBC comedy "Friends"

Had dual role in the comedy "Just Visiting," playing a 12th-century noblewoman and her 21st-century descendant

Co-starred with Johnathon Schaech and Molly Ringwald in "The Giving Tree"

Co-starred with Mark Wahlberg and Lou Diamond Phillips in "The Big Hit"

Returned to series TV as the lead in the NBC sitcom "Jesse"

Starred in the independent feature "Claudine's Return"

Cast in Tim Burton's "Mars Attacks!"

Had starring role in "Don't Tell Mom the Babysitter's Dead"

Feature lead in "Streets"

Cast as ditzy teenager, Kelly Bundy on Fox's "Married... With Children"

TV series debut in "Hearts of the City"

Made TV movie debut in "Grace Kelly"

Made film debut in "Jaws of Satan"

Made TV debut at the age of three months in "Days of Our Lives"

First TV speaking role in "Quincy"