Patrick Dempsey

Starred with Michelle Monaghan in the romantic comedy, "Made of Honor"

Co-starred with Amy Adams in the live-action, animated feature, "Enchanted"

Played the husband of Hilary Swank's character in "Freedom Writers"

Cast as Dr. Derek Shepherd in the ABC medical drama "Grey's Anatomy"; earned Golden Globe (2006, 2007) and SAG (2006) nominations for Best Actor

Cast in the HBO original movie "Iron Jawed Angels" based on womens' struggle for the right to vote in America

Co-starred with Reese Witherspoon in the romantic comedy "Sweet Home Alabama"

Portrayed Cass Chaplin (a semi-fictive Charles Chaplin Jr.) in the CBS miniseries "Blonde" based on Joyce Carol Oates' novel

Cast in a recurring role as the psycholigically disturbed brother of Lily (Sela Ward) on "Once and Again" (ABC); earned an Emmy (2001) nomination for Outstanding Guest Actor

Co-starred as a detective investigating a string of murders on a film set in "Scream 3"

Had recurring role as a closeted sportscaster dating lawyer Will Truman (Eric McCormack) in the NBC sitcom "Will & Grace"

Played title role in the biblical drama "Jeremiah" (aired in the USA in 2000 on PAX TV)

Modeled clothes for the J. Crew catalog

Starred in the CBS miniseries "A Season in Purgatory," adapted from the Dominick Dunne novel

Appeared as Brendan Fraser's college roommate in "With Honors"

Directorial debut as co-helmer (with then wife Rocky Parker) of "Ava's Magical Adventure"

Cast in the title role of the ABC miniseries "JFK: Reckless Youth"

Made Off-Broadway debut in a revival of "The Subject Was Roses"

Portrayed the young Meyer Lansky in "Mobsters"

Co-starred in "Coup de Ville"

Portrayed an amorous pizza delivery man in "Loverboy"

Breakthrough role as Ronald Miller, the loveable geek in "Can't Buy Me Love"

TV debut as Mike Damone in the short-lived CBS teen sitcom "Fast Times"

TV-movie debut as an epileptic teen in "A Fighting Choice" (ABC)

Film acting debut, "Heaven Help Us"

Appeared in San Francisco production of "Torch Song Trilogy"

Stage debut, "On Golden Pond," with Maine Acting Company

Won "Talent America" contest and the attention of a booking agent during the summer

Performed as juggler, magician and puppeteer before Elks clubs and community organizations

Raised in rural communities of Turner and Buckfield, Maine

Toured for a year in leading role of Eugene Jerome in the Neil Simon comedy-drama "Brighton Beach Memoirs"