Joan Cusack

Cast opposite Abigail Breslin in the family film, "Kit Kittredge: An American Girl"

Once again played on-screen siblings with real life brother John in "The Martian Child"

Co-starred with Frances McDormand, Jennifer Aniston and Catherine Keener in Nicole Holofcener's "Friends with Money"

Voiced Abby Mallard (aka Ugly Duckling) in the animated feature "Chicken Little"

Cast as Kate Hudson's sister in the comedy "Raising Helen"

Played a prep school's straight-laced principal opposite Jack Black in the Richard Linklater directed "School of Rock"

Starred as a Chicago high school teacher in ABC's "What About Joan"

Had a small role in Stephen Frears' "High Fidelity" starring her brother John

Played Hazel Huffman in the Tim Robbins-directed "Cradle Will Rock"

Voiced a yodeling cowgirl named Jessie, in the animated film "Toy Story 2"

Once again co-starred with brother John playing his secretary in the comedy "Grosse Pointe Blank"

Played Kevin Kline's bride-to-be whose life hinges on whether he is gay or not in the comedy "In & Out"; garnered second Best Supporting Actress Oscar nomination

Had a supporting role in the comedy, "Nine Months"

Had a rare dramatic TV role in "The Mother" (PBS) opposite Anne Bancroft

Played a murderous nanny in "Addams Family Values"

Appeared Off-Broadway in the Circle Repertory Company's "Brilliant Traces"

Earned a Best Supporting Actress Oscar nomination for her role as Melanie Griffith's best friend in "Working Girl"

Played on-screen siblings with real life brother John Cusack in Cameron Crowe's "Say Anything"

Made Off-Broadway debut in "Road"

Series regular debut, NBC's "Saturday Night Live"

TV-movie debut, "All Together Now"

First appearance alongside brother John in "Class"

Screen acting debut in "My Bodyguard"; her father also had small role

While in college joined The Ark, improvisational comedy group